Photo-allergic ResponsePhoto-allergic
response, typically redness or a more severe reaction, occurs only
after repeated exposure to a substance. In contrast to photo-toxicity,
photo-allergy is an immune system response, wherein antibodies develop
and react to what is perceived as a pathogen by the immune system. As
the name implies, the allergic response also depends on exposure to
light.
Description of Study and Results
A typical photo-allergy protocol was followed consisting of an induction period followed by a challenge period. In the induction period 25 human subjects were exposed to Oxofulleram; (0.3%) twice per week for 3 weeks, with 24 hour application of occluded patch. Subjects were then exposed to 3MED (3 x the Minimal Erythemal Dose), for a total of 6 exposures. The average erythema response over all data points for the inductio period was 0.73, and no adverse responses were noticed in any of the subjects. A 10 - 16 day rest period was allowed, and then the challenge period was initiated. The challenge period consisited of parallel control and test patches applied for 24 hours and 0.5 MED UV-B plus 4 J/cm^2 UV-A, with monitoring at 24, 48, and 72 hours, and a follow-up examination 3 days after the last observation. All observations were made by a trained dermatologist. No increase of erythema response was observed compared to control.
See Antioxidant/Anti-Erythema Effect on Human Skin for more details on the study and results.
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