Light Sensitization (Phototoxicity) After primary irritation, one of the most common tests of skin care ingredients is for light sensitization. A substance may not irritate alone, but in the presence of light may cause irritation in the form of redness, or more severe reactions. The retinoids (all-trans-retinoic acid, or Accutane), and retinol are known to cause light sensitivity in this manner, among many other ingredients.
Description of Study and Results
Oxofulleram
(0.3%) in grape seed oil (Combray) was applied by occluded (covered)
patch and left in place for 24 hours to 25 human subjects. A UV-A dose of 10 J/cm^2 and
UV-B dose of 0.5 MED (minimal erythema dose) was applied, the site was
then covered by a light impervious barrier which was left for 24 hours.
A trained dermatologist then monitored the exposed site, and
subsequently at 48 h and 72 hours, as well as a follow-up 3 days after
the last observation. No adverse reactions were observed in any of the subjects.
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