Singlet Oxygen Generation Singlet Oxygen (1O2)
is an excited, meta-stable form of oxygen that is very reactive, and
damaging to human cells. It is classified as a Reactive Oxygen Species
(ROS). It is produced typically by exposure of a sensitizing substance
to light. Singlet oxygen is produced in your skin naturally by UV
radiation, as there are natural sensitizers present in your skin. Singlet oxygen, among other ROS, is one of the contributing factors to
sunburn. Production of singlet oxygen is common among many ingredients,
and minimal generation of singlet oxygen by a cosmetics ingredient is
desired.
Description of Study and Results
Equal weight % solutions (0.1 mg/ml) of Oxofulleram and Vitamin E dissolved in chlorobenzene in open beakers with stirring were exposed to simulated solar radiation. 300 mg of adamantylideneadamantane was also dissolved in each solution. Each solution was irradiated under identical conditions for 7 hours. The dioxetane reaction product of singlet oxygen + adamantylideneadamantane was isolated and analyzed by 1H NMR spectroscopy. Each solution was irradiated under identical conditions for 7 hours.
The ratio of adamantylideneadamantane to dioxetane reaction product for the Vitamin E solution was 90:10, while the Oxofulleram solution was 94:6, indicating 40% less net single oxygen generation by Oxofulleram relative to Vitamin E under simulated solar irradiation.
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